Grubbs Cross Metathesis Reaction

It’s hard to get excited about a reaction with a 50% theoretical yield and an annoying separation waiting at the end.Fortunately there are some guidelines for CM that can make your time in the lab much more efficient…The seminal paper in this area came out of the Grubbs group ( Type I – Fast homodimerization; the homodimerization product is reactive Type II – Slow homodimerization; the homodimerization product is modestly reactive Type III – No homodimerization Type IV – Metathesis spectator A representative example (also from the Grubbs 2003 paper): When a 1:1 ratio of the two olefins is used, they see an 80% reaction yield.

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Although challenging, the possibility to perform aqueous metatheses has become an attractive alternative, not only because water is a more sustainable medium, but also to exploit biocompatible conditions.

All things being equal, higher dilution will favor intramolecular reactions.

But in metathesis as in life, things are never equal.

And unless you have a strained olefin in your system, the reactions are thermoneutral, so you don’t have to worry about an exotherm.

This makes for the perfect scenario to run reactions neat.


Comments Grubbs Cross Metathesis Reaction

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